Niguarda is a place of health care and culture. To know Niguarda means to come into contact with more than 4,100 health care workers, of whom 750 are physicians and more than 2,000 are nurses, health technicians, physical therapists, or midwives. There are 70 buildings for hospitalized patients and more than 200 clinics. It is a referral center for patients of all ages from every region of Italy.

Niguarda is the seat of the following services:
• 26 highly specialized national referral centers
• Tissue Bank
• Headquarters of the 118 Service for Milan and its provinces
• Mobile Unit for the management of major emergencies
• Poison Control Center
• Equestrian Rehabilitation Center “Vittorio Di Capua”
• Burn Unit
• Trauma Center
• Unipolar Spinal Unit
• Center for Rare Diseases (more than 100 pathologies treated)
• University program for Nursing Sciences
• MAPP Museo D'arte Paolo Pini (Paolo Pini Art Museum), officially recognized municipal museum.

Niguarda is one of the most active transplant centers in Italy.

Niguarda has a center for detoxification and treatment for the damage caused by smoking, and has a referral center for the treatment of tuberculosis at the Istituto Villa Marelli.